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ZIANA Gel is used on the skin for treatment of acne in patients 12 years or older.

• The most commonly reported adverse events were inflammation of the nose and throat, throat pain, dry skin, cough, and sinus inflammation.
• Stop ZIANA Gel and call your doctor if you develop watery or bloody diarrhea, or if your skin becomes very red, swollen, blistered, or crusted.
• Avoid excessive exposure to the sun, cold, and wind. Weather extremes can dry and burn the skin. Always use a sunscreen on skin treated with ZIANA Gel, even on cloudy days. Use other protective clothing, such as a hat, when you are out in the sun. Avoid the use of sunlamps and tanning booths. If your face becomes sunburned, stop treatment until your skin has healed.
• Do not get ZIANA Gel in your eyes or mouth, on your lips, on the corners of your nose, or on open wounds.
• Do not use ZIANA Gel if you have Crohn's disease, ulcerative colitis, or have developed colitis with past antibiotic use.
• Avoid medicated or abrasive soaps and cleaners, soaps and cosmetics that have a strong drying effect, and skin products that contain alcohol, astringents, spices, or lime.
• Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.